SCHNURRI-3 INHIBITION RESCUES SKELETAL FRAGILITY AND VASCULAR SKELETAL STEM CELL NICHE PATHOLOGY IN THE OIM MODEL OF OSTEOGENESIS IMPERFECTA

Schnurri-3 inhibition rescues skeletal fragility and vascular skeletal stem cell niche pathology in the OIM model of osteogenesis imperfecta

Abstract Osteogenesis imperfecta (OI) is a disorder of low bone mass and increased fracture risk due to a range of genetic variants that prominently include mutations in genes encoding type I collagen.While it is well known that OI reflects defects in the activity of bone-forming osteoblasts, it is currently unclear whether OI also reflects defects

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A multimodal approach for modeling engagement in conversation

Recently, engagement has emerged as a key variable explaining the success of conversation.In the perspective of human-machine interaction, an automatic assessment of engagement becomes crucial to better understand the dynamics of an interaction and to design socially-aware robots.This paper presents a predictive model of the level of engagement in

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